Internal Medicine
Shirin Afhami; Negin Esmailpour Bazaz; Alireza Khoshnevisan; Kourosh Sadeghi; Mahmood Reza Sarzaeem; Parastoo Amiri; Ehsan Rahimpour; Mahnaz Montazeri
Abstract
Introduction: The rational use of antibiotic prophylaxis before surgery can reduce surgical site infection, microbial resistance, and economic burden. Therefore, the present study was carried out to optimize the use of antibiotic prophylaxis before surgery using a ready-made drug package prepared in ...
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Introduction: The rational use of antibiotic prophylaxis before surgery can reduce surgical site infection, microbial resistance, and economic burden. Therefore, the present study was carried out to optimize the use of antibiotic prophylaxis before surgery using a ready-made drug package prepared in the pharmacy of Dr. Shariati Hospital.Materials and Methods: The current study is a semi-experimental intervention type, carried out in two stages before and after on 260 patients hospitalized in the heart surgery and neurosurgery departments of Dr. Shariati Hospital who were candidates for surgery and received antibiotic prophylaxis before surgery. A checklist containing patients ' information was completed before and after the preparation of antibiotic prophylaxis packages. Data were analyzed in spss18 software with descriptive and analytical statistics (p≤0.05).Results: Before and after the optimization of antibiotic use, a statistically significant difference was observed in the two study groups regarding dosage, administration intervals, time, and duration of administration. (P<0.001) A 63.42% reduction in the number of doses of antibiotic prophylaxis was observed after the implementation of optimization. Also, there was a 57.33% reduction in the cost of antibiotic prophylaxis after the implementation of optimization.Conclusion: The use of a ready-made drug package before surgery optimizes the use of antibiotic prophylaxis. Also, the economic burden caused by inappropriate use of prophylactic antibiotics for the patient and the hospital is significantly reduced with this method.